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Chemical & Systems BiologyCSB 210. Signal Transduction Pathways and Networks—The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics. CSB 220. Chemistry of Biological Processes—(Same as BIOC 220.) The principles of organic and physical chemistry as applied to biomolecules. Goal is a working knowledge of chemical principles that underlie biological processes, and chemical tools used to study and manipulate biological systems. Prerequisites: organic chemistry and biochemistry, or consent of instructor. CSB 240. Drug Discovery—The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering. CSB 260. Quantitative Chemical Biology—Current topics including protein and small molecule engineering, cell signaling sensors and modulators, molecular imaging, chemical genetics, combinatorial chemistry, in vitro evolution, and signaling network modeling. Prerequisites: undergraduate organic chemistry, and biochemistry or cell biology. CSB 270. Research Seminar—Guest speakers and discussion on current research in pharmacology. CSB 278. Introduction to Systems Biology—(Same as CS 278.) For biologists, engineers, and computer scientists. Experimental and computational approaches to modeling and analysis of complex biological systems. Topics: biological noise; simple signaling circuits (cascades, feedback, and feed-forward circuits); bistability and oscillations; large scale models; synthetic biology; and analysis of omics-scale data sets. Computational approached include ODE modeling, stochastic simulation, boolean networks, Bayesian approaches, and hybrid modeling. CSB 299. Directed Reading in Chemical and Systems Biology— Prerequisite: consent of instructor. CSB 399. Graduate Research—Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
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