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| Biosciences |
DBIO 201. Development and Disease Mechanisms—Mechanisms that direct human development from conception to birth. Conserved molecular and cellular pathways regulate tissue and organ development; errors in these pathways result in congenital anomalies and human diseases. Topics: molecules regulating development, cell induction, developmental gene regulation, cell migration, programmed cell death, pattern formation, stem cells, cell lineage, and development of major organ systems. Emphasis on links between development and clinically significant topics including infertility, assisted reproductive technologies, contraception, prenatal diagnosis, multiparity, teratogenesis, inherited birth defects, fetal therapy, adolescence, cancer, and aging.
4 units, Aut (Porzig, E; Kim, S; Kingsley, D; Scott, M)
DBIO 202. Assisted Reproductive Technologies—(Same as OBGYN 202.) Primary literature in basic and clinical science, and demonstrations of assisted reproductive technologies (ART). Techniques include in vitro fertilization covering micromanipulation procedures such as intracytoplasmic sperm injection and the culture of blastocysts, using mouse gametes, and pre-embryos. Class only may be taken for 1 unit. 2 units includes papers and attendance at clinical demonstrations. 3 units includes a term paper. Prerequisite: DBIO 201 recommended, or consent of instructors.
1-3 units, Win (Porzig, E; Behr, B)
DBIO 203. Advanced Genetics—(Same as BIOSCI 203, GENE 203.) For graduate students in Bioscience programs; may be appropriate for graduate students in other programs. The genetic toolbox. Examples of analytic methods, genetic manipulation, genome analysis, and human genetics. The use of genetic tools in dissecting complex biological pathways, developmental processes, and regulatory systems. Faculty-led discussion sections with evaluation of papers. Students with minimal experience in genetics should prepare by working out problems in college level textbooks.
4 units, Aut (Stearns, T; Barsh, G; Sidow, A; Kim, S)
DBIO 210. Developmental Biology—Current areas of research in developmental biology. How organismic complexity is generated during embryonic and post-embryonic development. The roles of genetic networks, induction events, cell lineage, maternal inheritance, cell-cell communication, and hormonal control in developmental processes in well-studied organisms such as vertebrates, insects, and nematodes. Team-taught. Students meet with faculty to discuss current papers from the literature. Prerequisite: graduate standing, consent of instructor. Recommended: familiarity with basic techniques and experimental rationales of molecular biology, biochemistry, and genetics.
5 units, Spr (Villeneuve, A; Fuller, M; Beachy, P)
DBIO 215. Frontiers in Biological Research—(Same as BIOC 215, GENE 215.) Literature discussion in conjunction with the Frontiers in Biological Research seminar series hosted by Biochemistry, Developmental Biology, and Genetics in which distinguished investigators present current work. Students and faculty meet beforehand to discuss papers from the speaker’s primary research literature. Students meet with the speaker after the seminar to discuss their research and future direction, commonly used techniques to study problems in biology, and comparison between the genetic and biochemical approaches in biological research.
1 unit, Aut, Win (Harbury, P; Brunet, A; Villeneuve, A)
DBIO 221. Current Issues in Aging—(Same as GENE 221, NENS 221.) Current research literature on genetic mechanisms of aging in animals and human beings. Topics include: mitochondria mutations, insulin-like signaling, sirtuins, aging in flies and worms, stem cells, human progeria, and centenarian studies. Prerequisite: GENE 203.
1-2 units, Win (Kim, S; Brunet, A; Rando, T), Spr (Kim, S)
DBIO 232. Topics in Regenerative Medicine—(Same as MI 232.) Forum. Students and researchers discuss current developments in regenerative medicine at Stanford to spark collaboration. Topics include novel applications in biological and chemical engineering, stem cell biology, biotechnology, and human disease. May be repeated for credit.
2 units, Aut, Win, Spr (Blau, H; Fuller, M)
DBIO 257. The Stem Cell: Science, Ethics, and Politics—(Same as HUMBIO 157.) The biology of stem cells. Their role in human development and potential for treating disease. Guest lectures by biologists, ethicists, and legal scholars. Prerequisites: HUMBIO 2A,B, or consent of instructor.
3 units, Spr (Nusse, R; Fuller, M; Porzig, E)
DBIO 273A. A Computational Tour of the Human Genome—(Same as BIOMEDIN 273A, CS 273A.) Genomes as the ultimate biological information medium, carrying instructions for every organism’s development, life cycle, and reproduction. Bioinformatics perspective. Advances in biology resulting from sequencing of human and related organisms. Genome sequencing: technologies, assembly, personalized sequencing. Functional landscape: genes, regulatory modules, repeats, RNA genes. Genome evolution: processes, comparative genomics, ultraconservation, exaptation. Topics may include population genetics and personalized genomics, ancient DNA, and metagenomics. Prerequisities: computational biology at the level of 262, 274, or BIOC 218.
3 units, Aut (Batzoglou, S; Bejerano, G)
DBIO 296. Stem Cell Biology and Regenerative Medicine—(Same as PATH 296.) For graduate and medical students. Embryonic and adult stem cells, including origin, regulation, self-renewal, differentiation, fate, and relationship to cancer; biological mechanisms and methods to translate findings to therapeutic applications. Medical students must enroll for 5 units; graduate students may choose to take only the basic science part for 3 units. Prerequisites: DBIO 201 and 210, or consent of instructor.
3-5 units, Win (Weissman, I; Fuller, M; Nusse, R)
DBIO 299. Directed Reading in Developmental Biology—Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)
DBIO 399. Graduate Research—Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)
