Molecular and Cellular Physiology

MCP 200. Cardiovascular Physiology—Offered jointly with the Department of Medicine. Lectures, small group instruction, clinical presentations, and lab demonstrations of normal and disordered human cardiovascular physiology. Prerequisite: understanding of general biochemistry.
5 units, Spr (Kobilka, B)

MCP 213. Special Topics in Molecular and Cellular Physiology— Introductory and advanced physiological topics agreed on by an instructor and students. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

MCP 216. Genetic Analysis of Behavior—(Same as NBIO 216.) Advanced seminar. Findings and implications of behavioral genetics as applied to invertebrate and vertebrate model systems. Topics include biological clocks, and sensation and central pattern generators. Relevant genetic techniques and historical perspective. Student presentation.
4 units, Win (Goodman, M; Clanindin, T)

MCP 222. Imaging: Biological Light Microscopy—(Same as BIOSCI 152, NBIO 222.) Survey of instruments which use light and other radiation for analysis of cells in biological and medical research. Topics: basic light microscopy through confocal fluorescence and video/digital image processing. Lectures on physical principles; involves partial assembly and extensive use of lab instruments. Lab. Prerequisites: some college physics, Biological Sciences core.
3 units, Spr (Smith, S; Dolmetsch, R)

MCP 232. Advanced Imaging Lab in Biophysics—(Same as BIOSCI 132/232, BIOPHYS 232.) Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, and optical trapping. Limited enrollment. Recommended: basic physics, Biological Sciences core or equivalent, and consent of instructor.
4 units, Spr (Block, S; Schnitzer, M; Smith, S;  Stearns, T)

MCP 256. How Cells Work: Energetics, Compartments, and Coupling in Cell Biology—Open to graduate and medical students, and advanced undergraduates. Dynamic aspects of cell behavior and function, including cellular energetics, homeostasis, heterogeneity of membranes, structure and function of organelles, solute and water transport, signaling and motility. Emphasis is on the principles of how coupling of molecular processes gives rise to essential functions at the cellular level. Mathematical models of cell function. Student presentations.
4 units, Spr (Goodman, M; Maduke, M)

MCP 258. Information and Signaling Mechanisms in Neurons and Circuits—(Same as NBIO 258.) How synapses, cells, and neural circuits process information relevant to a behaving organism. How phenomena of information processing emerge at several levels of complexity in the nervous system, including sensory transduction in molecular cascades, information transmission through axons and synapses, plasticity and feedback in recurrent circuits, and encoding of sensory stimuli in neural circuits.
5 units, Aut (Tsien, R; Baccus, S)

MCP 299. Directed Reading in Molecular and Cellular Physiology— Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

MCP 399. Graduate Research—Investigations sponsored by individual faculty members. Research fields include endocrinology, neuroendocrinology, and topics in molecular and cellular physiology. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum