Pathology
ATH 206: Epigenetics (BIO 156, BIO 256, GENE 206)
For graduate students; undergraduates by consent of instructor. Mechanisms by which phenotypes not determined by the DNA sequence are stably inherited in successive cell divisions. From the discovery of position-effect variegation in Drosophila in the 1920s to present-day studies of covalent modifications of histones and DNA methylation. Topics include: position effect, gene silencing, heterochromatin, centromere identity, genomic imprinting, histone code, variant histones, and the role of epigenetics in cancer. Prerequisite: background in genetics and molecular biology.
Terms: Spr, alternate years, not given next year | Units: 2
Instructors: Gozani, O.; Lipsick, J.
PATH 210: Stem Cells in Development and Disease
Molecular and cellular mechanisms underlying the basic self-renewal and differentiation properties of stem cells in multiple tissues and organisms. How abnormal stem cell behavior may contribute to diseases such as cancer. How to manipulate stem cell behavior in vitro or in vivo for therapeutic purposes. Classical papers and recent literatures in the field of stem cell biology. Open to graduate, medical, and advanced undergraduate students. Prerequisite: consent of instructor.
Terms: Aut | Units: 1-2
Instructors: Lu, B.
PATH 213: Gross Autopsy Pathology Laboratory
Examine/discuss unfixed dissected organs from current autopsies and correlate morphologic findings with the clinical history. Students view postmortem examinations and may participate (in a small group) in one postmortem examination with the assistance of residents and staff, and present the case to the class. Class scheduling is flexible. Additional unit for participation in a postmortem examination. Pre- or corequisite: HHD.
Terms: Aut, Win | Units: 2-3
Instructors: Regula, D.
PATH 218: Computational Analysis of Biological Images (GENE 218)
Physical and computational tools for acquisition, processing, interpretation, and archiving of biological images. Emphasis is on digital microscopy.
Terms: alternate years, given next year | Units: 2 | Grading: Med Opt
PATH 233: The Biology of Small Modulatory RNAs (GENE 233, MI 233)
Open to graduate and medical students. How recent discoveries of miRNA, RNA interference, and short interfering RNAs reveal potentially widespread gene regulatory mechanisms mediated by small modulatory RNAs during animal and plant development. Required paper proposing novel research.
Terms: Aut, not given this year, alternate years, given next year | Units: 2
PATH 234: Fundamentals of RNA Biology (GENE 234, MI 234)
For graduate or medical students and (if space allows) to active participants from other segments of the Stanford Community (e.g., TGR students); undergraduates by instructor consent. Fundamental issues of RNA biology, with the goal of setting a foundation for students to explore the expanding world of RNA-based regulation. Each week a topic is covered by a faculty lecture and journal club presentations by students.
Terms: Aut | Units: 2
Instructors: Chen, C.; Fire, A.; Sarnow, P.
PATH 240: Clinical Studies in Pathology I
Broad exposure to the practice of pathology in an academic medical center. Students are assigned a faculty mentor and work closely with pathology residents, fellows and faculty. Two months are spent in surgical pathology where students help examine surgical resection specimens and biopsies and participate in making a final diagnosis. One month is spent in autopsy pathology where students perform autopsy prosections and formulate final anatomic diagnoses under the supervision of faculty. May be combined with Clinical Studies in Pathology II, and two additional quarters of PATH 399, Directed Research, to fulfill a 12 month Post-Sophomore year Fellowship in Pathology. Prerequisite: MD candidate; instructor consent.
Terms: Aut, Win, Spr, Sum | Units: 3-9
Instructors: Higgins, J.; Natkunam, Y.
PATH 241: Clinical Studies in Pathology II
In-depth exposure to the practice of pathology for students who have completed Clinical Studies in Pathology I. Students are assigned a faculty mentor and work closely with pathology residents, fellows and faculty. Two months are spent in surgical pathology where students help examine surgical resection specimens and biopsies and participate in making a final diagnosis. One month is spent in autopsy pathology where students perform autopsy prosections and formulate final anatomic diagnoses under the supervision of faculty. Additional time may be spent observing in sub-specialty areas of pathology that include dermatopatholgy, neuropathology, renal pathology, lymph node pathology or cytology. May be combined with Clinical Studies in Pathology I and two additional quarters of PATH 399, Directed Research, to fulfill a 12-month Post-Sophomore year Fellowship in Pathology. Prerequisite: consent of instructor and successful completion of Clinical Studies in Pathology I (PATH 240).
Terms: Aut, Win, Spr, Sum | Units: 3-9
Instructors: Higgins, J.; Natkunam, Y.
PATH 296: Stem Cell Biology and Regenerative Medicine (DBIO 296)
For graduate and medical students. Embryonic and adult stem cells, including origin, regulation, self-renewal, differentiation, fate, and relationship to cancer; biological mechanisms and methods to translate findings to therapeutic applications. Medical students must enroll for 5 units; graduate students may choose to take only the basic science part for 3 units. Prerequisites: DBIO 201 and 210, or consent of instructor.
Terms: Win | Units: 3-5
Instructors: Fuller, M.; Nusse, R.; Weissman, I.
PATH 299: Directed Reading in Pathology
Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit
Instructors: Arber, D.; Axelrod, J.; Baron, E.; Berry, G.; Bogyo, M.; Bowen, R.; Butcher, E.; Cherry, A.; Cleary, M.; Connolly, A.; Cornbleet, P.; Cowan, T.; Crabtree, G.; Dadras, S.; Engleman, E.; Faix, J.; Fire, A.; Fontaine, M.; Foung, S.; Galel, S.; Galli, S.; Geaghan, S.; George, T.; Graef, I.; Hendrickson, M.; Higgins, J.; Jackson, P.; Kempson, R.; Lipsick, J.; Lu, B.; Michie, S.; Natkunam, Y.; Pollack, J.; Regula, D.; Sidow, A.; Sobel, R.; Sussman, H.; Vogel, H.; Wang, T.; Weissman, I.; Wernig, M.; West, R.; Zehnder, J.; van de Rijn, J.
PATH 399: Graduate Research
Students undertake investigations sponsored by individual faculty members. Opportunities at the molecular, cellular, and clinicopathologic levels. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit
Instructors: Arber, D.; Axelrod, J.; Baron, E.; Berry, G.; Bogyo, M.; Bowen, R.; Butcher, E.; Cherry, A.; Cleary, M.; Connolly, A.; Cornbleet, P.; Cowan, T.; Crabtree, G.; Dadras, S.; Engleman, E.; Faix, J.; Fire, A.; Fontaine, M.; Foung, S.; Galel, S.; Galli, S.; Geaghan, S.; George, T.; Graef, I.; Hendrickson, M.; Higgins, J.; Jackson, P.; Kempson, R.; Lipsick, J.; Lu, B.; Michie, S.; Natkunam, Y.; Pollack, J.; Regula, D.; Sidow, A.; Sobel, R.; Sussman, H.; Vogel, H.; Wang, T.; Weissman, I.; Wernig, M.; West, R.; Zehnder, J.; van de Rijn, J.