Pathology

PATH 206. Epigenetics—(Same as GENE 206.) For graduate students; undergraduates by consent of instructor. Mechanisms by which phenotypes not determined by the DNA sequence are stably inherited in successive cell divisions. From the discovery of position-effect variegation in Drosophila in the 20s to present-day studies of covalent modifications of histones and DNA methylation. Topics include: position effect, gene silencing, heterochromatin, centromere identity, genomic imprinting, histone code, variant histones, and the role of epigenetics in cancer. Prerequisite: background in genetics and molecular biology.
2 units, Win (Lipsick, J)

PATH 210. Stem Cells in Development and Disease—Molecular and cellular mechanisms underlying the basic self-renewal and differentiation properties of stem cells in multiple tissues and organisms. How abnormal stem cell behavior may contribute to diseases such as cancer. How to manipulate stem cell behavior in vitro or in vivo for therapeutic purposes. Classical papers and recent literatures in the field of stem cell biology. Open to graduate, medical, and advanced undergraduate students. Prerequisite: consent of instructor.
1-2 units, Spr (Lu, B)

PATH 218. Computational Analysis of Biological Images—Physical and computational tools for acquisition, processing, interpretation, and archiving of biological images. Emphasis is on digital microscopy.
2 units, alternate years, not given this year

PATH 233. The Biology of Small Modulatory RNAs—(Same as GENE 233, MI 233.) Open to graduate and medical students. How recent discoveries of miRNA, RNA interference, and short interfering RNAs reveal potentially widespread gene regulatory mechanisms mediated by small modulatory RNAs during animal and plant development. Required paper proposing novel research.
2 units, Aut (Fire, A; Chen, C), alternate years, not given next year

PATH 296. Stem Cell Biology and Regenerative Medicine—(Same as DBIO 296.) For graduate and medical students. Embryonic and adult stem cells, including origin, regulation, self-renewal, differentiation, fate, and relationship to cancer; biological mechanisms and methods to translate findings to therapeutic applications. Medical students must enroll for 5 units; graduate students may choose to take only the basic science part for 3 units. Prerequisites: DBIO 201 and 210, or consent of instructor.
3-5 units, Win (Weissman, I; Fuller, M; Nusse, R)

PATH 299. Directed Reading in Pathology—Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

PATH 399. Graduate Research—Investigations sponsored by individual faculty members. Opportunities at the molecular, cellular, and clinicopathologic levels. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

COGNATE COURSE

See department listings for course description. See degree requirements above or the program’s student services office for applicability of this course to a major or minor program.

 MI 211. Advanced Immunology I—(Same as IMMUNOL 201.)
3 units, Win (Chien, Y)